Surgery is the main treatment of colorectal cancer. Identify reported differences between advanced colorectal cancer patients treated in community oncology clinics and those enrolled in clinical trials. Chemotherapy drugs used to treat colorectal cancer. So it is a very relevant disease for this age group in fact. Methods. This is particularly true if oxaliplatin has been part of the treatment. In older patients with CRC, advanced age alone should not be the only criteria to preclude adjuvant or palliative chemotherapy that is effective in younger patients. If the tumour is close to the anus, a hole or an artificial anus (colostomy) may need to be made on the abdomen for excretion of stool after excision of the anus together with the tumour. We investigated how age, performance status (PS) and comorbidity influence treatment outcomes. This book Increasing age is a risk factor for the development of precancerous adenomas and colorectal cancer… Key words: Colon cancer, adjuvant chemotherapy, elderly, geriatric oncology, treatment-related decision making Introduction Colorectal cancer (CRC) is the second leading cause of cancer death in the United States, with an estimated 136,000 new cases and over 50,000 deaths in 2014 alone. Because most of these data were obtained during the 5‐FU era, the question remains whether proven agents and regimens are safe and effective in the greater population of elderly patients. Background. FOCUS2 adds to the totality of evidence because it is the first large randomised trial in colorectal cancer to have been designed specifically for frail elderly patients and to relate objective baseline measures of geriatric fitness with patient-related outcomes of chemotherapy. Adjuvant and Palliative Chemotherapy for Colon Cancer in the Elderly Patient Derek G. Power, MD, and Stuart M. Lichtman, MD There is an increasing body of evidence to suggest that geriatric patients can benefit from and tolerate standard chemotherapy similar to younger patients in the settings of both early and advanced stage colorectal cancer. Dan Li, Chenhan Zhong, Xiujun Tang, Linzhen Yu, Kefeng Ding, Ying Yuan, Competing nomograms help in the selection of elderly patients with colon cancer for adjuvant chemotherapy, Journal of Cancer Research and Clinical Oncology, 10.1007/s00432-018-2611-y, 144, 5, (909-923), (2018). 1-3 For breast cancer adjuvant chemotherapy, studies have shown that patients who receive dose-intense treatment fare better than those who do not. In addition, the treatment goals may differ from those in younger patients. J Clin Gastroenterol 2003; 36:228. Methods. Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the elderly. Patients The medical records of 69 patients with stage III colon cancer were reviewed. The aim is to investigate if frail, elderly patients with stage II-IV colorectal cancer, will profit from full comprehensive geriatric assessment and intervention before and during treatment with chemotherapy. Colorectal cancer primarily affects the elderly; however, much of the defining clinical research in this field has excluded subjects of advanced age or with a poor performance status, making it difficult for clinicians to interpret current treatment paradigms for their older patients. 54 Background: Since 2004 6 months of adjuvant Oxaliplatin containing regimens (OCR) has been standard of care for Stage III CRC despite cumulative neurotoxicity. Disparities in the use of chemotherapy and monoclonal antibody therapy for elderly advanced colorectal cancer patients in the community oncology setting. Colorectal cancer in the elderly. Chemotherapy Drugs Used for Colorectal Cancer The drug 5- fluorouracil (5-FU) has been the first choice to treat colorectal cancer for years. Adjuvant or neoadjuvant chemo is often given for a total of 3 to 6 months, depending on the drugs used. 1. CrossRef PubMed Google Scholar Patients and methods A retrospective single-centre study of 529 patients with … Chemotherapy Chemotherapy is an adjuvant therapy to control the spread of cancer. The need for adjuvant chemotherapy after colorectal cancer surgery in elderly patients is basically the same as that in younger patients. The use of adjuvant chemotherapy for localized breast cancer and colon cancer has been among the most important advances in medical oncology in terms of lives saved. Included were studies comparing postoperative fluorouracil plus leucovorin … Colorectal cancer is, one might say, a disease of the elderly with a median age at presentation of around 71-72. Objectives: To determine the benefits and harms of palliative chemotherapy in patients with locally advanced or metastatic colorectal cancer and to compare the outcomes for elderly and younger patients. 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